ONPATTRO® Infusion Therapy
About ONPATTRO® Infusion Therapy
ONPATTRO® is a prescription medicaine used to treat adults with polyneuropathy (nerve damage) caused by hereditarty transthyretin-mediated (hATTR) amyloidosis. It belongs to a class of drugs called RNA interference therapy (sometimes called a gene silencer). ONPATTRO® was designated an 'orphan medicine' (a medicine used in rare diseases.
Condition treated by this therapy
- Polyneuropathy caused by hereditary transthyretin-mediated hATTR
- People with hATTR amyloidosis that have an abnormality in the gene that carries the instruction code for TTR protein
The active substance in ONPATTRO®, pastisiran, is a small interfering RNA' (siRNA), a very short piece of synthetic genetic material of the cell responsible for production of defective transthyretin. This reduces production of defective transthyretin, therby reducing the formation of amyloids and relieving the symptoms of hATTR amyloidosis.
ONPATTRO® Price
The out-of-pocket ONPATTRO® price will vary depending on your insurance coverage. If you have questions about your coverage, contact your insurance provider.
No patient should go without necessary treatment due to financial limitations. If you have questions about financial assistance opportunities, contact a member of our Violet Health team.
What to Expect During ONPATTRO® Infusion Therapy
ONPATTRO® is administered as an intravenous infusion in form of an IV drip. You'll get an ONPATTRO® dose every 3 weeks. The recommended dose is 300 micrograms per kilogram of body weight once every 3 weeks.
Pre-treatment may include medicines that help lower chances of infusion-related reactions such as corcticosteroid medicines, paracetamnol, and medicines known as H1 and H2 blockers before receiving ONPATTRO®.
Your doctor will monitor you for any infusion-related reactions during and after the infusion. If you have any infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines.
ONPATTRO® Side Effects
The most common side effects of ONPATTRO® include:
- Respiratory infections (colds, sinus infections, and nasal congestion)
- Infusion-related reactions
- Reddening of the face or body (flushing)
- Body aches or pain, including pain in the back, neck or joints.
- Nausea
- Abdominal pain
- Dyspnea
- Headache
Treatment with ONPATTRO® lowers the amount of vitamin A inyour blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor. Low vitamin A levels can affect vision. If you develop problems with your vision (e.g., night blindness) while taking ONPATTRO®, talk to your doctor.
ONPATTRO® Infusion Therapy at Violet Health
Your comfort during ONPATTRO® infusion therapy at Violet Health is our priority. Our ONPATTRO® patients enjoy walk-up parking, complimentary entertainment and snacks, and a team of highly trained providers during each treatment. Plus, Violet Health’s evening and weekend hours and convenient city and rural locations make it easier to schedule your appointments.
Violet Health Infusion Centers provides infusion therapy for patients with rare, chronic, or complex conditions in a comfortable, patient-centered atmosphere.
Helpful Resources
Patient Forms
Before you attend your first appointment at Violet Health, please make sure to review the documents below. Please contact us if you have any questions!
Meet our Infusion Specialists
Jalal Thwainey M.D.
Medical Director
Emilie Wojcik, N.P.
Director of Clinical Services
For Provider
Simplify patient referrals and offer advanced treatment options with our infusion partnership program.
For Patient
There may be a better way to manage your condition – explore infusion therapy.