Our Therapies

SPEVIGO® Infusion Therapy

a paper cut out of a person with red spots all over them signifying a skin condition; on a plain beige background

About SPEVIGO® Therapy

SPEVIGO® is a targeted biologic medication, meaning it is made from living cells. It works like a blocker by attaching to a protein called interleukin-36 (or IL-36 for short) which is a protein that acts as an alarm bell. In conditions such as generalized pustular psoriasis (GPP), this alarm bell won't stop ringing which triggers a chain reaction in the body. This results in inflammation on the skin and lead to widespread eruption of painful pustules (pus-filled bumps) that can cover large areas of your body. GPP flares can be serious and eveb life-threatening if not treated.

How SPEVIGO® plays a role in managing inflammation

SPEVIGO® attaches to the IL-36 receptor. Think of it as putting a lock on a door that IL-36 tries to enter. By blocking the receptor, SPEVIGO® stops the inflammatory signals from getting through. This leads to a reduction and clearing of the pustules on the skin which relieves the pain and discomfort. This also calms down the widespread inflammation; helping you get back to feeling more like yourself.

Condition treated by this therapy

SPEVIGO® is FDA approved to treat generalized pustular psoriasis (or GPP for short) in adults and children 12 years and older who weigh at least 40 kg (88 lbs).

SPEVIGO® Price

The out-of-pocket SPEVIGO® price will vary depending on your insurance coverage. If you have questions about your coverage, contact your insurance provider.

At Violet Health, we believe no patient should go without necessary treatment due to financial limitations. If you have questions about financial assistance opportunities, contact a member of our Violet Health team.

What to Expect During SPEVIGO® Infusion Therapy

We advise you to please arrive early to your appointment well hydrated and well rested. Your doctor should check you for tuberculosis (TB) before starting Spevigo®. Tell your doctor if you've had TB in the past or have been around someone with TB.

When experiencing a flare, one of our experienced clinical staff members will administer SPEVIGO® as an intravenous (IV) infusion.

Your first infusion:

You'll recieeve a single 900mg dose through an IV line in your arm.
The infusion takes 90 minutes
Our healthcare team will monitor you during and after the infusion for any reactions
Many people start seeing improvement within days to a week.

If symptoms persist:

If your flare symptoms continue after 1 week, your doctor may give you an additional 900 mg dose
If your flare comes back after you've responded to treatment, you may receive a rescue dose
You can receive up to 3 total doses during a flare episode

For Preventing Future Flares (Maintenance Treatment)

If you and your doctor decide that maintenance treatment is right for you, SPEVIGO® can be given as subcutaneous injections (under the skin) to help prevent future flares.

SPEVIGO® Side Effects

Common side effects of SPEVIGO® in IV infusion form include (but are not limited to):

Fatigue
Nausea / Vomiting
Headache
Itching and/or itchy bumps
Bruising at the injection site
Urinary tract infection
Upper respiratory infections

Common side effects when SPEVIGO® is given as a subcutaneous injection for maintenance may include, but are not limited to:

Reactions at the injection site (bleeding, blistering, burning, pain, rash, redness, swelling, or itching)
Upper respiratory infections
Urinary tract infections

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Serious side affects can happen. If you experience any of the following symptoms, please alert clinical staff as soon as possible. All of our rooms are equipped with an emergency call button.

Fainting, dizziness or lightheadedness
Swelling of the face, throat or trouble swallowing
Trouble breathing
Throat tightening or wheezing
Severe itching, hives or redness all over your body
Chest tightness, fast heartbeat
Sweating

SPEVIGO® Therapy at Violet Health

Your comfort during SPEVIGO® therapy at Violet Health is our priority. Our SPEVIGO® patients enjoy walk-up parking, complimentary entertainment and snacks, and a team of highly trained providers during each treatment. Plus, Violet Health’s evening and weekend hours and convenient city and rural locations make it easier to schedule your appointments.

Need a ride? We offer free transportation.

Violet Health Infusion Centers provides infusion therapy for patients with rare, chronic, or complex conditions in a comfortable, patient-centered atmosphere.

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Helpful Resources

Patient Forms

Before you attend your first appointment at Violet Health, please make sure to review the documents below. Please contact us if you have any questions!